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Spindle cells are of mesenchymal origin and constitute a part of the body’s connective tissue. On cytologic examination these cells appear elongated with a fusiform or ovoid nucleus. The tissue of origin can be determined based on evidence of collagen, cartilage, bone, fat or myxomatous material formed by the tumor cells. Epithelial-Mesenchymal Transition (EMT) and lack of expression of cell adhesion molecules like cadherins is a primary process describing the pathogenetic mechanisms.[4,5] EMT has been postulated as a versatile mechanism that facilitates cellular reconstitution during embryonic development and when incited later in life, contributes to various pathologic processes.[6] Soft tissue spindle cell neoplasms may range from reactive lesions to benign and malignant tumors.[7] This heterogenous group of lesions includes those of neural, fibroblastic, myofibroblastic, myogenic, epithelial and vascular tumors. They are quite rare in the oral cavity and account for less than 1% of all the tumors of oral origin and 3% of the salivary gland tumors. The vast appearances and architectural patterns of the spindle cell tumors make the distinction from similar microscopic lesions quite enigmatic.[3,8] As the spindle cells contain both benign and malignant mimics, misclassification has the potential to result in either under or over treatment of the patient.[9] The tissue of origin can determine the biologic potential of the lesions.[3,10