Login

The peripheral nervous system (PNS) comprises all nervous tissue outside the brain and spinal cord. It is composed of nerves and scattered groups of ganglia. The cellular components of the nervous tissue include schwann cells, fibroblasts and perineurial cells. Neurogenic lesions are alterations from the normal pattern of these tissues or their precursors. Although they share a common neural origin, [1] they have variable clinical and biological behaviors. In the oral and maxillofacial region, lesions of neural origin are rare and represent 0.2–0.6% of [2] cases. Oral neural tumors (ONTs) may be either neoplastic or reactive in origin and they arise from distinguishable compartments of peripheral nerves, which are the axons, endoneurium, perineurium and epineurium. The endoneurium comprises fibroblasts, capillaries, macrophages and mast cells and surrounds axons which are formed by schwann cells. The perineurium consists of perineurial cells arranged in one or more concentric layers with collagen fibers while the [3] epineurium consists mainly of fibro adipose tissue.