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Tobacco and humans have a long-standing relationship, much like food and tea. Many uses of tobacco appear to have originated from snuffing. As snuffing implements are among the oldest tobaccorelated items yet discovered. Tobacco was chewed, eaten, drank (like tea), smeared on bodies (to kill lice and other parasites), and used in eye drops and enemas. In addition to being sniffed and smoked. It was also blown into the faces of warriors before battle, over agricultural fields before planting, and over ladies before sex. Tobacco was thought to have medical benefits, such as analgesic and antibacterial properties, and could be used to treat a number of ailments. Tobacco was often offered to gods in religious rituals. Nicotiana tabacum and Nicotiana rustica are the Americas' oldest plants, having evolved in the Andes near Peru and Ecuador. People first learned about Nicotina tabacum and Nicotiana rustica, as well as other species like tomatoes, potatoes, maize, cacao, and rubber, when they travelled from Asia to the American continents beyond the Bering Straight land bridge around 18 000 years ago. Tobacco use had spread over the American continent and Cuba by the time Christopher Columbus landed in 1492..[1]