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“Cytodiagnosis is the diagnosis of a assumed pathologic tissue by a microscopic examination of the cells in the sample.” “Oral medicine is the discipline of dentistry concerned with the oral health care of medically compromised patients and with the diagnosis and non surgical management of medically related disorders or conditions affecting the oral and maxillofacial region”. The common happening of soft-tissue lesions within the oral cavity offers a challenging diagnostic problem for the dentist. Lesions caused by trauma or chronic irritation are probably the most widespread, especially when the number and type of routine attack upon the oral mucous membranes are considered. Since then cytology began to be used in the oral cavity as a cytopathologic diagnostic tool. Cytology has been useful to diagnose oral diseases since Papanicolaou and Traut validated it for diagnosing neoplasias of the uterine cervix. Unfortunately, it was a failure, mainly due to its bad employment in processes where it was impossible to obtain good diagnostic results.