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Antibiotic resistance has emerged as major health related issue since last two decades.The introduction of successive classes of antibiotics have been made ineffective by bacteria by developing a variety of resistance mechanisms.There have been growing epidemics of infections due to gram negative bacteria especially from Enterobacteriaceae family, which are resistant to many classes of antibiotics.1 β-lactam antimicrobial agents are the major group of antimicrobials used for treatment of gram negative bacterial infections. Besides extended spectrum penicillins and cephalosporins, the carbapenems have become important options for medication especially in intensive care unit patients.2 Carbapenems are agents with an exceptionally broad spectrum of activity.3 Because of its stable nature against extended spectrum beta lactamase (ESBL) and AmpC enzyme producing gram negative bacilli including Enterobacteriaceae, carbapenems are used as a last resort against many multi drug resistant gram negative bacteria. 4