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Orthodontics and Dentofacial Orthopaedics is a field that has been around since the early 1700s. Just like any scientific field orthodontics has evolved throughout the ages. Better understanding of the biological basics of tooth movement along with new innovative discoveries and technologies, have en abled orthodontists to achieve improved outcomes and enhance the overall pa tient experience. Artificial Intelligence (AI) has been applied across dentistry in general—and orthodontics in particular—to address a variety of challenges. Early efforts to integrate AI into dental and orthodontic practice took the form of knowledge-based expert systems (ES).